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KMID : 0361020070500060537
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Korean Journal of Otolaryngology - Head and Neck Surgery
2007 Volume.50 No. 6 p.537 ~ p.541
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Clinical Assessment and Management of Papillary Thyroid Carcinoma with Coexistent Hashimoto’s Thyroiditis
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Shim Youn-Sang
Lee Yong-Sik
Lee Guk-Haeng
Lee Byeong-Cheol
Jung Yeon-Woo
Lee Ji-Woong
Lee Ka-Hee
Lee Yun-Yong
Lee Seung-Sook
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Abstract
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Background & Objectives: The frequency of co-occurence of Hashimoto’s thyroiditis and papillary thyroid carcinoma has been variously reported to range from 0.3% to 38%, and the association of these two diseases is still controversial. The aim of our study is to determine the relationship between these two entities, and in this paper, we compare the clinical characteristics of patients with and without histopathological evidence of Hashimoto’s thyroiditis.
Subjects & Methods: Among 366 patients treated for thyroid nodules (including benign nodules and thyroid cancers) during the period of July 2004 - June 2005, 278 patients (male versus female=1 : 7.9) with papillary thyroid carcinoma were included in this study.
Results: Hashimoto’s thyroiditis co-occurred with papillary thyroid carcinoma in 68 of 278 patients (24.5%), compared with 0 of 21 patients (0%) with other thyroid malignancies. The age at presentation (median, 43.9 years), tumor size (median, 1.31 cm), methods of diagnostic evaluation, and the extent of surgery had not influenced by the presence of Hashimoto’s thyroiditis. However, TNM stage, AMES stage, MACIS score were slightly lower and the proportion of female patients (1 : 67) was higher in patients with Hashimoto’s thyroiditis.
Conclusion: These results suggest that patients who have papillary thyroid carcinoma may have more favorable prognosis in the co-ocurring Hashimoto’s thyroiditis. Further studies are required to confirm the long-term prognostic association between these two diseases.
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KEYWORD
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Papillary Thyroid Carcinoma, Hashimoto’s Thyroiditis
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